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Submit ReviewRo 19-4603
说明： Benzodiazepine inverse agonist
化学名： 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester
纯度： ≥99% (HPLC)
生物活性 for Ro 19-4603
Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.
技术数据 for Ro 19-4603
| 分子量 | 319.38 |
| 公式 | C15H17N3O3S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 99632-94-7 |
| PubChem ID | 127382 |
| InChI Key | ZIGMMUKDYCABPW-UHFFFAOYSA-N |
| Smiles | CN1CC2=C(N=CN2C2=C(SC=C2)C1=O)C(=O)OC(C)(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ro 19-4603
参考文献 for Ro 19-4603
参考文献是支持产品生物活性的出版物。
Wong and Skolnick (1992) High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690
June et al (1995) Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol. J.Pharmacol.Exp.Ther. 274 1105 PMID: 7562476
June et al (1998) The novel benzodiazepine inverse agonist RO19-4603 antagonises ethanol motivated behaviours: neuropharmacological studies. Brain Res. 784 256 PMID: 9518641
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关键词: Ro 19-4603, Ro 19-4603 supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, Ro19-4603, 1995, Tocris Bioscience
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