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RO-3

Cat. No. 3052 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective P2X3 and P2X2/3 antagonist
化学名： 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RO-3

RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

技术数据 for RO-3

分子量 302.37
公式 C16H22N4O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1026582-88-6
PubChem ID 11289644
InChI Key PYNPWUIBJMVRIG-UHFFFAOYSA-N
Smiles NC1=NC(N)=NC=C1CC2=C(C(C)C)C=C(OC)C(OC)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RO-3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.24 100

制备储备液 for RO-3

以下数据基于产品分子量 302.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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产品说明书 for RO-3

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for RO-3

参考文献是支持产品生物活性的出版物。

Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132 PMID: 16465177

Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409 PMID: 18042830

Gever et al (2006) Pharmacology of P2X channels. Eur.J.Physiol. 452 513

If you know of a relevant reference for RO-3, please let us know.

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关键词: RO-3, RO-3 supplier, Selective, P2X2, P2X2/3, antagonists, Receptors, Purinergic, purinoceptors, P2X, 3052, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.