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Ro 51

Cat. No. 4391 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent P2X3 and P2X2/3 antagonist
化学名： 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ro 51

Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.

技术数据 for Ro 51

分子量 474.29
公式 C17H23IN4O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1050670-85-3
PubChem ID 24883277
InChI Key PAYROHWFGZADBR-UHFFFAOYSA-N
Smiles NC1=NC(NC(CO)CO)=NC=C1OC2=C(C(C)C)C=C(OC)C(I)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ro 51

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.43 100
ethanol 47.43 100

制备储备液 for Ro 51

以下数据基于产品分子量 474.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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产品说明书 for Ro 51

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ro 51

参考文献是支持产品生物活性的出版物。

Jahangir et al (2009) Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain. Bioorg.Med.Chem.Lett. 19 1632 PMID: 19231178

Syed and Kennedy (2012) Pharmacology of P2X receptors WIREs.Membr.Transp.Signal. 1 16

If you know of a relevant reference for Ro 51, please let us know.

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关键词: Ro 51, Ro 51 supplier, Ro51, Potent, selective, P2X3, P2X2/3, P2X, purinergic, receptors, antagonists, purinoceptors, Receptors, 4391, Tocris Bioscience

1 篇 Ro 51 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ro 51 的部分引用包括：

Lu et al (2019) Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat.Commun. 10 1029 PMID: 30833673

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.