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Submit ReviewRo 67-4853
说明： Positive allosteric modulator of group I mGlu receptors
化学名： (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester
纯度： ≥99% (HPLC)
生物活性 for Ro 67-4853
Ro 67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).
技术数据 for Ro 67-4853
| 分子量 | 325.36 |
| 公式 | C19H19NO4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 302841-89-0 |
| PubChem ID | 9949202 |
| InChI Key | RQBUXEUMZZQUFY-UHFFFAOYSA-N |
| Smiles | O=C(NC(OCCCC)=O)C2C3=C(C=CC=C3)OC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ro 67-4853
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.54 | 100 |
制备储备液 for Ro 67-4853
以下数据基于产品分子量 325.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.07 mL | 15.37 mL | 30.74 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.15 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.07 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
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产品说明书 for Ro 67-4853
参考文献 for Ro 67-4853
参考文献是支持产品生物活性的出版物。
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 98 13402 PMID: 11606768
Hempstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124
If you know of a relevant reference for Ro 67-4853, please let us know.
关键词: Ro 67-4853, Ro 67-4853 supplier, Ro67-4853, PAM, positive, allosteric, modulator, modulators, metabotropic, glutamate, receptor, 1, enhancer, mGlu1, receptors, Glutamate, (Metabotropic), Group, I, Receptors, 4347, Tocris Bioscience
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