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Submit ReviewROS 234 dioxalate
Discontinued Product
2034 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： Potent H3 antagonist
化学名： N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate
纯度： ≥99% (HPLC)
生物活性 for ROS 234 dioxalate
ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).
技术数据 for ROS 234 dioxalate
| 分子量 | 421.37 |
| 公式 | C13H15N5.2C2H2O4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1781941-93-2 |
| PubChem ID | 56972188 |
| InChI Key | JKTBCMILCFDKEJ-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)=O.O=C(O)C(O)=O.C1(CCCNC2=NC3=C(C=CC=C3)N2)=CNC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ROS 234 dioxalate
参考文献 for ROS 234 dioxalate
参考文献是支持产品生物活性的出版物。
Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 S55 PMID: 12013409
Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663
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关键词: ROS 234 dioxalate, ROS 234 dioxalate supplier, Potent, H3, antagonists, Receptors, Histamine, histaminergic, ROS234, dioxalate, 2034, Tocris Bioscience
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Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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