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RP 6306

Cat. No. 8031 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective PKMYT1 inhibitor
化学名： (S)-2-Amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethylpyrrolo[2,3-b]pyridine-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RP 6306

RP 6306 is a potent and selective PKMYT1 inhibitor (IC50 = 3.1 nM). In vivo, it inhibits CCNE1-amplified tumor cell growth in mouse xenograft models. RP 6306 is orally bioavailable.

技术数据 for RP 6306

分子量 324.38
公式 C18H20N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2719793-90-3
PubChem ID 156869388
InChI Key ARBRHWRTXPWZGN-UHFFFAOYSA-N
Smiles O=C(C1=C(N)N(C2=C(C)C(O)=CC=C2C)C3=C1C=C(C)C(C)=N3)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RP 6306

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.44 100

制备储备液 for RP 6306

以下数据基于产品分子量 324.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for RP 6306

参考文献是支持产品生物活性的出版物。

Gallo et al (2022) CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. Nature 604 749 PMID: 35444283

Szychowski et al (2022) Discovery of an orally bioavailable and selective PKMYT1 inhibitor, RP-6306. J.Med.Chem. 65 10251 PMID: 35880755

If you know of a relevant reference for RP 6306, please let us know.

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关键词: RP 6306, RP 6306 supplier, RP6306, potent, selective, inhibitor, kinase, inhibitors, inhibits, kinases, CDK1, orally, bioavailable, cancer, CCNE1, Subfamily, 8031, Tocris Bioscience

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