RS 100329 hydrochloride

Cat. No. 1325 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, subtype-selective α_1A antagonist

化学名： 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RS 100329 hydrochloride

RS 100329 hydrochloride is a subtype-selective α_1A-adrenoceptor antagonist (pK_i = 9.6 for human cloned α_1A receptors). Displays 126- and 50-fold selectivity over human α_1B and α_1D receptors respectively. Active in vivo.

许可信息

Sold with the permission of Roche Bioscience

技术数据 for RS 100329 hydrochloride

分子量	462.89
公式	C₂₀H₂₅F₃N₄O₃.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	1215654-26-4
PubChem ID	11340200
InChI Key	CWVABCXVOAVUJL-UHFFFAOYSA-N
Smiles	Cl.CC1=CNC(=O)N(CCCN2CCN(CC2)C2=C(OCC(F)(F)F)C=CC=C2)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RS 100329 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		100

制备储备液 for RS 100329 hydrochloride

以下数据基于产品分子量 462.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.8 mL	21.6 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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产品说明书 for RS 100329 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RS 100329 hydrochloride

参考文献是支持产品生物活性的出版物。

Conley et al (2001) The role of α₁-adrenoceptors and 5-HT_1A receptors in the control of the micturition reflex in male anaesthetized rats. Br.J.Pharmacol. 133 61 PMID: 11325795

Shannon Kava et al (1998) α_1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol. 123 1359 PMID: 9579731

Williams et al (1999) In vitro α₁-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α_1A-adrenoceptor selective antagonists. Br.J.Pharmacol. 127 252 PMID: 10369480

If you know of a relevant reference for RS 100329 hydrochloride, please let us know.

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关键词: RS 100329 hydrochloride, RS 100329 hydrochloride supplier, Potent, subtype, selective, α1A-adrenoceptor, alpha1A-adrenoceptor, a1a-adrenoceptor, antagonists, α1a-adrenergic, alpha1a-adrenergic, a1a-adrenergic, receptors, RS100329, hydrochloride, Adrenergic, Alpha-1, Receptors, 1325, Tocris Bioscience

3 篇 RS 100329 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RS 100329 hydrochloride 的部分引用包括：

Ishii and Sugimura (2015) Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug. Front Cell Neurosci 8 42618 PMID: 25584077

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582

Cleary et al (2004) Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens. Br J Pharmacol 143 745 PMID: 15451776

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