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Submit ReviewRS 79948 hydrochloride
说明： Potent and selective α2 antagonist
化学名： (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for RS 79948 hydrochloride
RS 79948 hydrochloride is a α2-adrenoreceptor antagonist (Kd values are; 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat).
许可信息
Sold with the permission of Roche Bioscience
技术数据 for RS 79948 hydrochloride
| 分子量 | 400.96 |
| 公式 | C19H28N2O3S.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 186002-54-0 |
| PubChem ID | 9908991 |
| InChI Key | DZTZUOBWDBPPJQ-BQBHMPFISA-N |
| Smiles | [H][C@]12C4=C(C=C(OC)C=C4)CCN1C[C@]3([H])[C@](N(S(=O)(CC)=O)CCC3)([H])C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RS 79948 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25 |
制备储备液 for RS 79948 hydrochloride
以下数据基于产品分子量 400.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.98 mL | 49.88 mL | 99.76 mL |
| 1.25 mM | 2 mL | 9.98 mL | 19.95 mL |
| 2.5 mM | 1 mL | 4.99 mL | 9.98 mL |
| 12.5 mM | 0.2 mL | 1 mL | 2 mL |
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产品说明书 for RS 79948 hydrochloride
参考文献 for RS 79948 hydrochloride
参考文献是支持产品生物活性的出版物。
Clark et al (1989) (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α2-adrenoceptor antagonist. J. Med. Chem. 32 2034 PMID: 2570150
Hume et al (1996) Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors. Eur.J.Pharmacol. 317 67 PMID: 8982721
Uhlen et al (1998) [3H]RS79948-197 binding to rat, guinea pig and pig α2A-, α2B and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719
If you know of a relevant reference for RS 79948 hydrochloride, please let us know.
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4 篇 RS 79948 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RS 79948 hydrochloride 的部分引用包括：
Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552
Chen et al (2019) Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor. Cell Reports 29 2936 PMID: 31801061
Qu et al (2019) Structural Basis of the Diversity of Adrenergic Receptors. Cell Reports 29 2929 PMID: 31801060
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