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Submit Review(RS)-AMPA
说明： Selective AMPA agonist
化学名： (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
纯度： ≥99% (HPLC)
生物活性 for (RS)-AMPA
(RS)-AMPA is a prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors.
Active Enantiomer, Inactive Enantiomer and Hydrobromide Salt also available.
技术数据 for (RS)-AMPA
| 分子量 | 186.17 |
| 公式 | C7H10N2O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 77521-29-0 |
| PubChem ID | 1221 |
| InChI Key | UUDAMDVQRQNNHZ-UHFFFAOYSA-N |
| Smiles | CC1=C(CC(N)C(O)=O)C(O)=NO1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (RS)-AMPA
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.86 | 10 温和加热 |
制备储备液 for (RS)-AMPA
以下数据基于产品分子量 186.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 53.71 mL | 268.57 mL | 537.14 mL |
| 0.5 mM | 10.74 mL | 53.71 mL | 107.43 mL |
| 1 mM | 5.37 mL | 26.86 mL | 53.71 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
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产品说明书 for (RS)-AMPA
参考文献 for (RS)-AMPA
参考文献是支持产品生物活性的出版物。
Honore et al (1982) The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 38 173 PMID: 6125564
Krogsgaard-Larsen et al (1980) New class of glutamate agonist structurally related to ibotenic acid. Nature 284 64 PMID: 6101908
If you know of a relevant reference for (RS)-AMPA, please let us know.
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关键词: (RS)-AMPA, (RS)-AMPA supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, 74341-63-2, 0169, Tocris Bioscience
19 篇 (RS)-AMPA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (RS)-AMPA 的部分引用包括：
Rojas et al (2013) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol 83 106 PMID: 23066089
Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606 PMID: 20826795
Ye et al (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology 157 PMID: 31207251
Mahajan et al (2011) Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience 189 305 PMID: 21620933
Fakira et al (2012) Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. Mol Cell Neurosci 51 22 PMID: 22789621
Gangadharan et al (2011) Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest 121 1608 PMID: 21383497
Biou et al (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. Proc Natl Acad Sci U S A 105 1038 PMID: 18195348
Fedele and Raiteri (1996) Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: an in vivo cyclic GMP microdialysis study in rat cerebellum. Br J Pharmacol 117 1133 PMID: 8882607
Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br J Pharmacol 119 590 PMID: 8894183
Netzahualcoyotzi and Tapia (2015) Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates. Acta Neuropathol Commun 3 27 PMID: 25968178
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS One 10 e0131430 PMID: 26102354
Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports 3 282 PMID: 25254342
Schenk et al (2003) Regulated delivery of AMPA receptor subunits to the presynaptic membrane. EMBO J 22 558 PMID: 12554656
Chen et al (2002) Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa J Virol 76 9407 PMID: 12186923
Angelantonio et al (2015) Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Front Cell Neurosci 9 409 PMID: 26528137
Nygaard et al (2015) Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Oncoscience 1 82 PMID: 25593989
Suyama et al (2017) Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. Elife 6 PMID: 28762946
Guntupalli et al (2017) GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem 292 8186 PMID: 28377502
Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886
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AMPA receptor agonist works effectively.
By
Karthik krishnamurthy on 10/26/2018
分析类型： In Vitro
种属： Rat
细胞系/组织： motor neurons
Used to measure calcium influx in motor neurons upon AMPA receptor stimulation. 50 micromolar AMPA was added to the bath during live imaging of motor neurons loaded with calcium indicator FURA-2 AM
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