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Discontinued Product
1073 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Selective group II mGlu antagonist
化学名： (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
生物活性 for (RS)-APICA
(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.
技术数据 for (RS)-APICA
| 分子量 | 257.18 |
| 公式 | C10H12NO5P |
| 储存 | Desiccate at +4°C |
| CAS Number | 170847-18-4 |
| PubChem ID | 4694355 |
| InChI Key | ZNQZXIHSJUDIKL-UHFFFAOYSA-N |
| Smiles | NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (RS)-APICA
参考文献 for (RS)-APICA
参考文献是支持产品生物活性的出版物。
Krenz et al (2000) Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 83 1188 PMID: 10712449
Xi et al (2002) Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 300 162 PMID: 11752112
Ma et al (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 7 1195
关键词: (RS)-APICA, (RS)-APICA supplier, Selective, group, II, antagonists, mGlur, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, (Metabotropic), 1073, Tocris Bioscience
2 篇 (RS)-APICA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (RS)-APICA 的部分引用包括：
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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