(RS)-MCPG disodium salt

Name: ( RS )-MCPG disodium salt
Brand: Tocris Bioscience
SKU: 3696
Rating: 5 (1 reviews)

Cat. No. 3696 2 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)

化学名： (RS)-α-Methyl-4-carboxyphenylglycine disodium salt

纯度： ≥99% (HPLC)

说明书

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (RS)-MCPG disodium salt

(RS)-MCPG disodium salt is a sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer also available.

技术数据 for (RS)-MCPG disodium salt

分子量	253.16
公式	C₁₀H₉NNa₂O₄
储存	Store at RT
纯度	≥99% (HPLC)
PubChem ID	90488871
InChI Key	YGOTXTUQJLFNHB-UHFFFAOYSA-L
Smiles	[Na+].[Na+].CC(N)(C([O-])=O)C1=CC=C(C=C1)C([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (RS)-MCPG disodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	25.32	100

制备储备液 for (RS)-MCPG disodium salt

以下数据基于产品分子量 253.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.95 mL	19.75 mL	39.5 mL
5 mM	0.79 mL	3.95 mL	7.9 mL
10 mM	0.4 mL	1.98 mL	3.95 mL
50 mM	0.08 mL	0.4 mL	0.79 mL

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产品说明书 for (RS)-MCPG disodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (RS)-MCPG disodium salt

参考文献是支持产品生物活性的出版物。

Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333 PMID: 7992387

Joly et al (1995) Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 15 3970 PMID: 7751958

Eaton et al (1993) Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol.Mol.Pharmacol.Sect. 244 195

If you know of a relevant reference for (RS)-MCPG disodium salt, please let us know.

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关键词: (RS)-MCPG disodium salt, (RS)-MCPG disodium salt supplier, Non-Selective, mGlur, antagonists, Group, I, II, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, 1303994-09-3, Non-selective, mGlu, 3696, Tocris Bioscience

2 篇 (RS)-MCPG disodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (RS)-MCPG disodium salt 的部分引用包括：

Hajime et al (2022) Activation of Glutamate Transport Increases Arteriole Diameter in v ivo: Implications for Neurovascular Coupling. Front Cell Neurosci 16 831061 PMID: 35308116

David D et al (2019) Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron 102 420-434.e8 PMID: 30826183

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Suppression of mGluR action triggered by glutamate application.

By Sergiy Sylantyev on 10/15/2020

种属： Human

细胞系/组织： Stem cell - derived neurons

(RS)-MCPG disodium salt was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG disodium salt works as expected; the effects and time interval for response development are same with those of (RS)-MCPG, but the salt is much easier soluble.

参考文献

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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