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Submit ReviewRU 28318, potassium salt
说明： Potent, selective mineralocorticoid receptor antagonist
别名： Oxprenoate potassium
化学名： (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt
纯度： ≥98% (HPLC)
生物活性 for RU 28318, potassium salt
RU 28318, potassium salt is a potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.
技术数据 for RU 28318, potassium salt
| 分子量 | 440.66 |
| 公式 | C25H37O4K |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 76676-34-1 |
| PubChem ID | 23677972 |
| InChI Key | HXJITUGMCJCKCE-UYOQDFFISA-M |
| Smiles | [K+].[H][C@@]12CC[C@@](O)(CCC([O-])=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@H](CCC)CC2=CC(=O)CC[C@]12C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RU 28318, potassium salt
参考文献 for RU 28318, potassium salt
参考文献是支持产品生物活性的出版物。
Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213 PMID: 9879980
Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853 PMID: 6323881
Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199 PMID: 10607876
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关键词: RU 28318, potassium salt, RU 28318, potassium salt supplier, Potent, selective, mineralocorticoid, antagonists, Aldosterone, Receptors, RU28318, potassium, salt, Oxprenoate, Mineralocorticoid, Receptor, 1672, Tocris Bioscience
6 篇 RU 28318, potassium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RU 28318, potassium salt 的部分引用包括：
Luther et al (2011) Aldosterone decreases glucose-stimulated Ins secretion in vivo in mice and in murine islets. Diabetologia 54 2152 PMID: 21519965
Dorey et al (2012) Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 37 2870 PMID: 22948976
Sabourin et al (2016) Transient receptor potential canonical (TRPC)/Orai1-dependent store-operated Ca2+ channels: New targets of aldosterone in cardiomyocytes. J.Biol.Chem. 291 13394 PMID: 27129253
Mayanagi et al (2008) Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem 283 31183 PMID: 18772142
Crochemore et al (2005) Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. J Neurosci 10 790 PMID: 15940303
Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. Proc Natl Acad Sci U S A 25 4288 PMID: 15858055
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