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Submit ReviewRU-SKI 43 hydrochloride
说明： Hedgehog acyltransferase (Hhat) inhibitor; cell permeable
化学名： 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride
纯度： ≥98% (HPLC)
生物活性 for RU-SKI 43 hydrochloride
RU-SKI 43 hydrochloride is a hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.
技术数据 for RU-SKI 43 hydrochloride
| 分子量 | 423.01 |
| 公式 | C22H30N2O2S.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 90488982 |
| InChI Key | JBBKLHJLHRGJSQ-UHFFFAOYSA-N |
| Smiles | O=C(CNCC(CC)C)N1CCC3=C(C=CS3)C1COC2=CC(C)=CC=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RU-SKI 43 hydrochloride
参考文献 for RU-SKI 43 hydrochloride
参考文献是支持产品生物活性的出版物。
Petrova et al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247 PMID: 23416332
Petrova et al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263 PMID: 24469057
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关键词: RU-SKI 43 hydrochloride, RU-SKI 43 hydrochloride supplier, RU-SKI43, Hydrochloride, Hedgehog, acyltransferase, inhibitors, inhibits, Hh, sonic, ShhN, Hhat, palmitoylation, Signaling, 4886, Tocris Bioscience
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