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Submit ReviewRuBi-Glutamate
说明： Caged glutamate; excited by visible wavelengths
化学名： (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt
生物活性 for RuBi-Glutamate
RuBi-Glutamate is a ruthenium-bipyridine-trimethylphosphine caged glutamate that can be excited by visible wavelengths and releases glutamate after one- or two-photon excitation. Has high quantum efficiency and can be used at low concentrations, partly avoiding blockade of GABAergic transmission seen with other caged glutamate compounds. Displays high spatial resolution and generates excitatory responses in individual dendritic spines with physiological kinetics.
MNI-caged-L-glutamate (Cat. No. 1490) also available.
许可信息
Sold under licence from Columbia University
技术数据 for RuBi-Glutamate
| 分子量 | 970.54 |
| 公式 | C28H32N5O4PRu.2NaPF6 |
| 储存 | Store at -20°C |
| CAS Number | 2417096-44-5 |
| PubChem ID | 90488860 |
| InChI Key | SQQVSHWHIPVYSZ-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].[Ru++].CP(C)C.F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F.NC(CCC([O-])=O)C([O-])=O.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CN=C(C=C1)C1=CC=CC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RuBi-Glutamate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 19.41 | 20 |
制备储备液 for RuBi-Glutamate
以下数据基于产品分子量 970.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 5.15 mL | 25.76 mL | 51.52 mL |
| 1 mM | 1.03 mL | 5.15 mL | 10.3 mL |
| 2 mM | 0.52 mL | 2.58 mL | 5.15 mL |
| 10 mM | 0.1 mL | 0.52 mL | 1.03 mL |
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产品说明书 for RuBi-Glutamate
参考文献 for RuBi-Glutamate
参考文献是支持产品生物活性的出版物。
Fino et al (2009) RuBi-Glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines. Front.Neural Circuits 3 1 PMID: 19506708
Salierno et al (2010) A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes. J.Inorg.Biochem. 104 418 PMID: 20060592
If you know of a relevant reference for RuBi-Glutamate, please let us know.
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关键词: RuBi-Glutamate, RuBi-Glutamate supplier, Caged, Glutamate, mGluR, iGluR, Receptors, agonists, ionotropic, metabotropic, Miscellaneous, Compounds, 3574, Tocris Bioscience
6 篇 RuBi-Glutamate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RuBi-Glutamate 的部分引用包括：
Mitchell et al (2019) Probing Single Synapses via the Photolytic Release of Neurotransmitters Front Synaptic Neurosci 11 PMID: 31354469
Kazemipour et al (2019) Kilohertz frame-rate two-photon tomography. Nat Methods 16 778 PMID: 31363222
Roberto et al (2013) Ruthenium polypyridyl phototriggers: from beginnings to perspectives. Philos Trans A Math Phys Eng Sci 371 20120330 PMID: 23776299
Paz et al (2018) Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac. Neuropharmacology 137 309 PMID: 29758221
Blaesse et al (2015) μ-Opioid Receptor-Mediated Inhibition of Intercalated Neurons and Effect on Synaptic Transmission to the Central Amygdala. Neuroscience 35 7317 PMID: 25972162
Tazerart et al (2020) Spike-timing-dependent plasticity rule for single, clustered and distributed dendritic spines. Nat Commun 11 4276 PMID: 32848151
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RuBi-Glutamate 的评论
平均评分: 5 (Based on 1 Review.)
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Anonymous on 06/01/2020
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Periaqueductal gray
Recording from a DA neuron in the periaqueductal gray. A 6 x 6 grid was used to locally uncage Rubi-glutamate (300 micromolar) in an area surrounding the neuron. Representative trace showing the responses to each focal stimulation in current-clamp mode.
Light sensitive.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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