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Rufinamide

Cat. No. 3828 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Prolongs inactivation of sodium channels; anticonvulsant
别名： CGP 33101
化学名： 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Rufinamide

Rufinamide is a board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

技术数据 for Rufinamide

分子量 238.19
公式 C10H8F2N4O
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 106308-44-5
PubChem ID 129228
InChI Key POGQSBRIGCQNEG-UHFFFAOYSA-N
Smiles O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rufinamide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.82 100

制备储备液 for Rufinamide

以下数据基于产品分子量 238.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.2 mL 20.99 mL 41.98 mL
5 mM 0.84 mL 4.2 mL 8.4 mL
10 mM 0.42 mL 2.1 mL 4.2 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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参考文献 for Rufinamide

参考文献是支持产品生物活性的出版物。

Rogawski et al (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 273 PMID: 16621450

Arroyo (2007) Rufinamide. Neurotherapeutics 4 155 PMID: 17199032

White et al (2008) The anticonvulsant profile of rufin. (CGP 33101) in rodent seizure models. Epilepsia 49 1213 PMID: 18325020

If you know of a relevant reference for Rufinamide, please let us know.

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关键词: Rufinamide, Rufinamide supplier, CGP33101, sodium, channels, voltage-gated, voltage-dependent, NaV, Na+, prolongs, inactivation, anticonvulsant, anticonvulsive, antiepileptic, CGP, 33101, Voltage-gated, Sodium, Channels, 3828, Tocris Bioscience

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