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Submit ReviewS 14506 hydrochloride
说明： Highly potent 5-HT1A agonist; displays unique binding mechanism
化学名： 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for S 14506 hydrochloride
S 14506 hydrochloride is a highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.
技术数据 for S 14506 hydrochloride
| 分子量 | 443.94 |
| 公式 | C24H26FN3O2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 286369-38-8 |
| PubChem ID | 131905 |
| InChI Key | HWLZKPKZVOLFGK-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC2=C(C=CC=C2C=C1)N1CCN(CCNC(=O)C2=CC=C(F)C=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for S 14506 hydrochloride
参考文献 for S 14506 hydrochloride
参考文献是支持产品生物活性的出版物。
Lima et al (1997) Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. J.Neural Transm. 104 1059 PMID: 9503258
Milligan et al (2001) S 14506: novel receptor coupling at 5-HT1A receptors. Neuropharmacology 40 334 PMID: 11166326
Colpaert et al (1992) S 14506: a novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. Drug Dev.Res. 26 21
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关键词: S 14506 hydrochloride, S 14506 hydrochloride supplier, potent, 5-HT1A, agonists, Serotonin, Receptors, S14506, hydrochloride, 1771, Tocris Bioscience
1 篇 S 14506 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 S 14506 hydrochloride 的部分引用包括：
Walory et al (2018) Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int J Mol Sci 19 PMID: 30347827
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.