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说明： Positive allosteric modulator of AMPA receptors
化学名： (3aS)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide
纯度： ≥98% (HPLC)
生物活性 for S 18986
S 18986 is a positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant.
技术数据 for S 18986
| 分子量 | 224.28 |
| 公式 | C10H12N2O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 175340-20-2 |
| PubChem ID | 637863 |
| InChI Key | MNTIJYGEITVWHU-SNVBAGLBSA-N |
| Smiles | O=S2(C1=CC=CC=C1N(CCC3)[C@@]3([H])N2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for S 18986
参考文献 for S 18986
参考文献是支持产品生物活性的出版物。
Desos et al (1996) Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator. Bioorg.Med.Chem.Lett. 6 3003
Lockhart et al (2000) (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. Eur.J.Pharmacol. 401 145 PMID: 10924919
Bourasset et al (2005) Neuropharmacokinetics of a new α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab.Dispos. 33 1137 PMID: 15860654
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关键词: S 18986, S 18986 supplier, S18986, pam, positive, allosteric, modulators, potentiators, ampa, cognitive, enhancers, enhancement, brain, penetrant, bbb, AMPA, Receptors, 3911, Tocris Bioscience
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