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S 32826

Cat. No. 3404 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3404 has been discontinued.

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说明： Potent autotaxin inhibitor
化学名： [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt
纯度： ≥98% (HPLC)
说明书
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生物活性 技术数据 说明书 参考文献

生物活性 for S 32826

S 32826 is an inhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).

技术数据 for S 32826

分子量 441.45
公式 C21H34NO4PNa2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1103672-43-0
PubChem ID 71311878
InChI Key DGRFALMFDGBLCP-UHFFFAOYSA-L
Smiles [Na+].[Na+].CCCCCCCCCCCCCC(=O)NC1=CC=C(CP([O-])([O-])=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for S 32826

参考文献是支持产品生物活性的出版物。

Ferry et al (2008) S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J.Pharmacol.Exp.Ther. 327 809 PMID: 18755937

Li et al (2011) Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Mol.Cancer 10 18 PMID: 21314984

Gaetano et al (2009) Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells. Mol.Carcinogenesis 48 801

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关键词: S 32826, S 32826 supplier, S32826, autotaxin, atx, inhibits, inhibitors, LPA, lysophosphatidic, acid, lipids, enpp2, lysophospholipases, phospholipases, Autotaxin, 3404, Tocris Bioscience

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