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Submit Review(S)-4-Carboxy-3-hydroxyphenylglycine
Discontinued Product
0320 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Group I mGlu antagonist; also group II mGlu agonist
别名： (S)-4C3HPG
纯度： ≥98% (HPLC)
生物活性 for (S)-4-Carboxy-3-hydroxyphenylglycine
(S)-4-Carboxy-3-hydroxyphenylglycine is a competitive antagonist at group I mGlu1a/1a receptors, mixed effect at mGlu5a/5b receptors; agonist at group II metabotropic glutamate receptors.
Racemate also available.
技术数据 for (S)-4-Carboxy-3-hydroxyphenylglycine
| 分子量 | 211.17 |
| 公式 | C9H9NO5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 85148-82-9 |
| PubChem ID | 5311455 |
| InChI Key | GXZSAQLJWLCLOX-ZETCQYMHSA-N |
| Smiles | OC1=C(C(O)=O)C=CC([C@]([H])(N)C(O)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (S)-4-Carboxy-3-hydroxyphenylglycine
参考文献 for (S)-4-Carboxy-3-hydroxyphenylglycine
参考文献是支持产品生物活性的出版物。
Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system Neuroscience 52 481 PMID: 7680790
Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370 PMID: 8182479
Kingston et al (1995) Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes. Neuropharmacology 34 887 PMID: 8532170
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
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关键词: (S)-4-Carboxy-3-hydroxyphenylglycine, (S)-4-Carboxy-3-hydroxyphenylglycine supplier, competitive, Group, I, antagonists, group, II, agonists, mGlur, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3, (S)-4C3HPG, (Metabotropic), 0320, Tocris Bioscience
1 篇 (S)-4-Carboxy-3-hydroxyphenylglycine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (S)-4-Carboxy-3-hydroxyphenylglycine 的部分引用包括：
Lee and Flavell (2014) Inhibition and enhancement of contextual fear memory destabilization. Front Behav Neurosci 8 144 PMID: 24808841
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