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(S)-(-)-5-Iodowillardiine

Cat. No. 0307 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly potent and subtype-selective kainate agonist
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (S)-(-)-5-Iodowillardiine

Demonstrates high affinity for the kainate receptor subtype hGluK1 (formerly hGluR5) (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formerly hGluR6).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

技术数据 for (S)-(-)-5-Iodowillardiine

分子量 325.06
公式 C7H8IN3O4
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 140187-25-3
PubChem ID 447196
InChI Key AXXYLTBQIQBTES-BYPYZUCNSA-N
Smiles O=C(N1)N(C[C@]([H])(N)C(O)=O)C=C(I)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-(-)-5-Iodowillardiine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1.1eq. NaOH 8.12 25

制备储备液 for (S)-(-)-5-Iodowillardiine

以下数据基于产品分子量 325.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 12.31 mL 61.53 mL 123.05 mL
1.25 mM 2.46 mL 12.31 mL 24.61 mL
2.5 mM 1.23 mL 6.15 mL 12.31 mL
12.5 mM 0.25 mL 1.23 mL 2.46 mL

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产品说明书 for (S)-(-)-5-Iodowillardiine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (S)-(-)-5-Iodowillardiine

参考文献是支持产品生物活性的出版物。

Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40 3645 PMID: 9357531

Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595 PMID: 1371315

Swanson et al (1998) Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 53 942 PMID: 9584222

Wong et al (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 14 3881 PMID: 7515954

Thompson et al (1996) Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol. 117 331P

If you know of a relevant reference for (S)-(-)-5-Iodowillardiine, please let us know.

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关键词: (S)-(-)-5-Iodowillardiine, (S)-(-)-5-Iodowillardiine supplier, potent, subtype, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, GluR5, GluK1, 0307, Tocris Bioscience

2 篇 (S)-(-)-5-Iodowillardiine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-(-)-5-Iodowillardiine 的部分引用包括：

Pollok and Reiner (2020) Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization. Proc Natl Acad Sci U S A 117 25851 PMID: 32999066

Pansiot et al (2010) Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat. Proc Natl Acad Sci U S A 5 e10916 PMID: 20532231

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