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Submit Review(S)-AMPA
说明： Selective AMPA agonist; active isomer of (RS)-AMPA (Cat. No. 0169)
化学名： (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
纯度： ≥99% (HPLC)
生物活性 for (S)-AMPA
(S)-AMPA is an active enantiomer of AMPA (EC50 = 3.5 μM).
NPEC-caged-(S)-AMPA, Inactive Enantiomer and Racemate also available.
技术数据 for (S)-AMPA
| 分子量 | 186.17 |
| 公式 | C7H10N2O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 83643-88-3 |
| PubChem ID | 158397 |
| InChI Key | UUDAMDVQRQNNHZ-YFKPBYRVSA-N |
| Smiles | [H][C@@](N)(C(O)=O)CC1=C(C)ON=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (S)-AMPA
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 9.31 | 50 |
制备储备液 for (S)-AMPA
以下数据基于产品分子量 186.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 10.74 mL | 53.71 mL | 107.43 mL |
| 2.5 mM | 2.15 mL | 10.74 mL | 21.49 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 25 mM | 0.21 mL | 1.07 mL | 2.15 mL |
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产品说明书 for (S)-AMPA
参考文献 for (S)-AMPA
参考文献是支持产品生物活性的出版物。
Falch et al (1998) Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. J.Med.Chem. 41 2513 PMID: 9651156
Hansen et al (1983) Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. J.Med.Chem. 26 901 PMID: 6133955
Lauridsen et al (1985) Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. J.Med.Chem. 28 668 PMID: 2859375
If you know of a relevant reference for (S)-AMPA, please let us know.
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关键词: (S)-AMPA, (S)-AMPA supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, 0254, Tocris Bioscience
13 篇 (S)-AMPA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (S)-AMPA 的部分引用包括：
Gasull-Camôs Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex. Neuropharmacology 139 41 PMID: 29940206
Temkin et al (2017) The Retromer Supports AMPA Receptor Trafficking During LTP. Neuron 94 74 PMID: 28384478
Wagner et al (2019) Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell Rep 28 11 PMID: 31269433
Langner et al (2017) Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms. Neurochem Res 42 838 PMID: 27444613
Bell et al (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. PLoS One 6 7066 PMID: 25967870
Jackson et al (2010) Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One 5 e11962 PMID: 20694145
Limon et al (2007) Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus. Neuroreport 104 15526 PMID: 17881566
Park et al (2016) Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation. Invest Ophthalmol Vis Sci 57 508 PMID: 26868754
Lussier et al (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. Proc Natl Acad Sci U S A 31 3077 PMID: 21414928
Underhill (2007) Hypoxic injury of isolated axons is independent of ionotropic glutamate receptors. Neurobiol Dis 25 284 PMID: 17071096
Fairless et al (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID: 23516458
Oh et al (2012) Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells. EMBO Rep 7 e47846 PMID: 23110111
Pooler et al (2013) Physiological release of endogenous tau is stimulated by neuronal activity. J Neurosci 14 389 PMID: 23412472
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Test of AMPA effect on VGCCs-generated transmembrane current.
By
Sergiy Sylantyev on 12/10/2023
分析类型： In Vitro
种属： Mouse
细胞系/组织： Arcuate nucleus
10 μM AMPA was used to clarify the input of AMPA receptors into 5HT-1B receptors - activated modulation of voltage-gated calcium channel gating. Left: control. Right: the effect of activation of 5HT-1B and AMPA receptors on transmembrane current through VGCCs evoked upon membrane depolarization. Blue trace: control; red trace: 5HT-1B and AMPA receptors activation.
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