(S)-Equol

Name: ( S )-Equol
Brand: Tocris Bioscience
SKU: 6158

Cat. No. 6158 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6158 has been discontinued.

View all Estrogen and Related Receptors products.

说明： Potent estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist

化学名： (3S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol

纯度： ≥98% (HPLC)

说明书

引用文献

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for (S)-Equol

(S)-Equol is a potent estrogen receptor β (ERβ) agonist (EC₅₀ = 65 nM). Exhibits 13-fold selectivity for ERβ over ERα. Atheroprotective. Protects against t-BHP induced apoptosis and attenuates ER stress in HUVECs. Activates Nrf2 signaling in vitro and in vivo. Inhibits tumor growth. Also dihydrotestosterone antagonist in vivo.

技术数据 for (S)-Equol

分子量	242.27
公式	C₁₅H₁₄O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	531-95-3
PubChem ID	91469
InChI Key	ADFCQWZHKCXPAJ-GFCCVEGCSA-N
Smiles	OC1=CC=C([C@H]2COC3=CC(O)=CC=C3C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (S)-Equol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (S)-Equol

参考文献是支持产品生物活性的出版物。

Yuan et al (2016) Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer. Oncotarget. 7 42585 PMID: 27323858

Zhang et al (2016) Equol attenuates atherosclerosis in apolipoprotein e-deficient mice by inhibiting endoplasmic reticulum stress via activation of Nrf2 in endothelial cells. PLoS One. 11 e0167020 PMID: 27907038

Muthyala et al (2004) Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg.Med.Chem. 12 1559 PMID: 15018930

Setchell et al (2005) S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am.J.Clin.Nutr. 81 1079 PMID: 15883431

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关键词: (S)-Equol, (S)-Equol supplier, agonist, estrogen, receptor, beta, ERb, ERbeta, ERβ, Nrf2, Estrogen, and, Related, Receptors, Androgen, Receptor, 6158, Tocris Bioscience

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Pathways for (S)-Equol

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.