(S)-MCPG

Name: ( S )-MCPG
Brand: Tocris Bioscience
SKU: 0337
Rating: 5 (1 reviews)

Cat. No. 0337 24 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)

化学名： (S)-α-Methyl-4-carboxyphenylglycine

纯度： ≥99% (HPLC)

说明书

引用文献 (24)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (S)-MCPG

(S)-MCPG is an active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist.

Racemate also available.

技术数据 for (S)-MCPG

分子量	209.2
公式	C₁₀H₁₁NO₄
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	150145-89-4
PubChem ID	446355
InChI Key	DNCAZYRLRMTVSF-JTQLQIEISA-N
Smiles	N[C@](C)(C(O)=O)C1=CC=C(C(O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-MCPG

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	1.1eq. NaOH	20.92	100

制备储备液 for (S)-MCPG

以下数据基于产品分子量 209.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.78 mL	23.9 mL	47.8 mL
5 mM	0.96 mL	4.78 mL	9.56 mL
10 mM	0.48 mL	2.39 mL	4.78 mL
50 mM	0.1 mL	0.48 mL	0.96 mL

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产品说明书 for (S)-MCPG

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (S)-MCPG

参考文献是支持产品生物活性的出版物。

Bordi et al (1996) Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology 35 1557 PMID: 9025103

Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333 PMID: 7992387

Jane et al (1993) Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of 1S,3R-ACPD induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology 32 725 PMID: 7689710

Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br. J. Pharmacol. 117 1493 PMID: 8730745

If you know of a relevant reference for (S)-MCPG, please let us know.

按标靶查看相关产品

关键词: (S)-MCPG, (S)-MCPG supplier, mGlur, Group, I, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, II, mGlu2, mGlu3, mGluR2, mGluR3, antagonists, Non-selective, mGlu, 0337, Tocris Bioscience

24 篇 (S)-MCPG 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-MCPG 的部分引用包括：

Navarrete et al (2012) Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol 10 e1001259 PMID: 22347811

Akerboom et al (2012) Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci 32 13819 PMID: 23035093

Platt et al (2012) Striatal DA transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS One 7 e36397 PMID: 22570709

Shinoda et al (2010) Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neurons. PLoS One 5 e10390 PMID: 20436928

Gu et al (2015) miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun 6 6789 PMID: 25858512

Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051 PMID: 21123660

Nieus et al (2014) Regulation of output spike patterns by phasic inhibition in cerebellar granule cells. Front Cell Neurosci 8 246 PMID: 25202237

Bagayogo and Dreyfus (2009) Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway. ASN Neuro 1 PMID: 19570026

Szokol et al (2015) Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Elife 9 49 PMID: 25762896

Rosa et al (2015) Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. J Neurosci 4 PMID: 26274565

Stephen et al (2015) Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling. Proc Natl Acad Sci U S A 35 15996 PMID: 26631479

Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830

Reissner et al (2010) A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity. J Neurosci 30 8797 PMID: 20592201

Matthies et al (2000) Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus. Learn Mem 7 227 PMID: 10940323

Min et al (1999) Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors. Proc Natl Acad Sci U S A 96 9932 PMID: 10449797

Vogt and Nicoll (1999) Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. Proc Natl Acad Sci U S A 96 1118 PMID: 9927703

Dunaevsky et al (1999) Developmental regulation of spine motility in the mammalian central nervous system. Proc Natl Acad Sci U S A 96 13438 PMID: 10557339

Colwell et al (1996) Regulation of N-MthD.-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors? Front Cell Neurosci 93 1200 PMID: 8577740

Kumar and Foster (2004) Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores. J Neurophysiol 91 2437 PMID: 14762159

Melis et al (2004) Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons. J Neurosci 24 10707 PMID: 15564588

Paladini et al (2003) DA controls the firing pattern of DA neurons via a network feedback mechanism. Nat Neurosci 100 2866 PMID: 12604788

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923

Bender et al (2006) Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci 26 4166 PMID: 16624937

Fukunaga et al (2007) Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol 151 870 PMID: 17502847

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(S)-MCPG as a blocker of mGluR action.

By Sergiy Sylantyev on 05/26/2019

分析类型： In Vitro

种属： Rat

细胞系/组织： Hippocampus

When mGluRs were suppressed with 1 mM (S)-MCPG, NMDAR effect was not enough powerful to generate action potentials in response to repetitive electrical stimulation of neural tissue. Figure: evoked post-synaptic potentials with action potentials (under control) and without action potentials (after application of MCPG.

PMID: 23395378

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