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Submit Review(S)-(-)-5-Fluorowillardiine
说明： Very potent AMPA agonist
化学名： (S)-(-)-α-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)pyridinepropanoic acid
纯度： ≥98% (HPLC)
生物活性 for (S)-(-)-5-Fluorowillardiine
A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).
技术数据 for (S)-(-)-5-Fluorowillardiine
| 分子量 | 217.16 |
| 公式 | C7H8FN3O4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 140187-23-1 |
| Smiles | O=C(C(F)=CN1C[C@@](N)([H])C(O)=O)NC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (S)-(-)-5-Fluorowillardiine
参考文献 for (S)-(-)-5-Fluorowillardiine
参考文献是支持产品生物活性的出版物。
Hawkins et al (1995) Binding of the new radioligand (S)-[3H]-AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardine. Neuropharmacology 34 405 PMID: 7566471
Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40 3645 PMID: 9357531
Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595 PMID: 1371315
Wong et al (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 14 3881 PMID: 7515954
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关键词: (S)-(-)-5-Fluorowillardiine, (S)-(-)-5-Fluorowillardiine supplier, potent, selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, 0306, Tocris Bioscience
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