(S)-PFI 2 hydrochloride

Cat. No. 5400 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)

化学名： 8-Fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride

纯度： ≥97% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (S)-PFI 2 hydrochloride

(S)-PFI 2 hydrochloride is a negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC₅₀ = 1 μM) compared to the active enantiomer.

Active Analog also available.

许可信息

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary on the SGC website.

技术数据 for (S)-PFI 2 hydrochloride

分子量	535.98
公式	C₂₃H₂₅F₄N₃O₃S.HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	1627607-88-8
PubChem ID	91691132
InChI Key	ZADKZNVAJGEFLC-BOXHHOBZSA-N
Smiles	O=C(N4CCCC4)[C@H](CC3=CC=CC(C(F)(F)F)=C3)NS(C2=CC1=C(C(F)=C2)CNCC1)(=O)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-PFI 2 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	53.6	100
	ethanol	10.72	20

制备储备液 for (S)-PFI 2 hydrochloride

以下数据基于产品分子量 535.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.33 mL	18.66 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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产品说明书 for (S)-PFI 2 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (S)-PFI 2 hydrochloride

参考文献是支持产品生物活性的出版物。

Barsyte-Lovejoy et al (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.U S A 111 12853 PMID: 25136132

If you know of a relevant reference for (S)-PFI 2 hydrochloride, please let us know.

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1 篇 (S)-PFI 2 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-PFI 2 hydrochloride 的部分引用包括：

Judson et al (2018) Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential. Cell Stem Cell 22 177 PMID: 29395054

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