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SA-15-P

Cat. No. 8050 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dual inhibitor of LAG3 interaction with both MHCII and FGL1
化学名： N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SA-15-P

SA-15-P is a dual inhibitor of the interaction of lymphocyte activation gene 3 (LAG3) with both the major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1) (IC50 values from TR-FRET assay are 4.2 μM and 6.5 μM respectively).

技术数据 for SA-15-P

分子量 428.49
公式 C26H24N2O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 852846-00-5
PubChem ID 4786555
InChI Key IYGLJCOGIQDUAE-UHFFFAOYSA-N
Smiles O=C(C1=CC=CO1)NC2=CC=C(C=C2)OCC(C3=C(C)N(CC4=CC=CC=C4)C(C)=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SA-15-P

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.85 100

制备储备液 for SA-15-P

以下数据基于产品分子量 428.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for SA-15-P

参考文献是支持产品生物活性的出版物。

Abdel-Rahman et al (2023) Discovery of first-in-class small molecule inhibitors of lymphocyte activation gene 3 (LAG-3). ACS Med.Chem.Lett. 14 629 PMID: 37197466

If you know of a relevant reference for SA-15-P, please let us know.

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关键词: SA-15-P, SA-15-P supplier, SA15P, LAG3, inhibitor, interaction, MHCII, major, histocompatibility, complex, fibrinogen, like, protein, 1, FGL1, lymphocyte, activation, gene, immune, checkpoint, Immune, Checkpoints, 8050, Tocris Bioscience

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