SAHM1

Cat. No. 6477 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Notch pathway inhibitor; prevents Notch complex assembly

纯度： ≥95% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SAHM1

SAHM1 is a notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

技术数据 for SAHM1

分子量	2196.58
公式	C₉₄H₁₆₂N₃₆O₂₃S
序列	AERLRRRIXLCRXHHST (Modifications: Ala-1 = N-terminal Ac & β-Ala, X = (S)-2-(4-pentenyl)alanine, X-9 and X-13 stapled together with a double bond)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2050906-89-1
PubChem ID	137919859
InChI Key	ADWKVIAAKDSBNE-VHQDTIAVSA-N
Smiles	[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SAHM1

溶解性	Soluble to 1 mg/ml in water

产品说明书 for SAHM1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SAHM1

参考文献是支持产品生物活性的出版物。

Ashley et al (2015) Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 116 2598 PMID: 25914241

Bagheri et al (2018) Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 12 304 PMID: 28482141

KleinJan et al (2018) The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 142 76 PMID: 29111218

If you know of a relevant reference for SAHM1, please let us know.

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关键词: SAHM1, SAHM1 supplier, Notch, pathway, inhibitors, inhibits, MAML1, complex, assembly, stapled, peptide, Other, Signaling, Stapled, Peptides, 6477, Tocris Bioscience

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