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Submit ReviewSakura 6
说明： Promoter of SERT and nNOS interaction
纯度： ≥95% (HPLC)
生物活性 for Sakura 6
Sakura 6 is a synthetic serotonin transporter (SERT)-binding peptide. Promotes interaction of SERT and neuronal nitric oxide synthase, reducing SERT activity and cell surface SERT, increases auto-inhibition, reduces synaptic 5-HT release and reduces firing in the dorsal raphe nucleus. Induces an acute depressive phenotype in a mouse model of depression.
技术数据 for Sakura 6
| 分子量 | 599.73 |
| 公式 | C31H45N5O7 |
| 序列 |
ADWV (Modifications: Ala-1= N-Cyclohexylethyl-Ala) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2490708-79-5 |
| InChI Key | XLTJIDLKXSSWKU-MUSDWVDSSA-N |
| Smiles | O=C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](C(C)C)C(O)=O)=O)=O)[C@H](C)NCCC3CCCCC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Sakura 6
参考文献 for Sakura 6
参考文献是支持产品生物活性的出版物。
Sun et al (2022) Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science 378 390 PMID: 36302033
关键词: Sakura 6, Sakura 6 supplier, sakura6, sert, serotonin, transporter, nNOS, neuronal, nitric, oxide, synthase, peptide, 5HT, autoinhibition, depressant, DRN, dorsal, raphe, nucleus, 5-HT, Transporters, 7897, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.