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Submit ReviewSalbutamol hemisulfate
说明： β2-adrenoceptor agonist
别名： Albuterol
化学名： α1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol hemisulfate
纯度： ≥98% (HPLC)
生物活性 for Salbutamol hemisulfate
Salbutamol hemisulfate is a selective β2-adrenergic agonist with 29-fold higher selectivity for β2 over β1 receptors. Salbutamol elevates fibroblast growth factor 20 (FGF20) in nigrostriatal neurons, and is neuroprotective in a mouse model of Parkinson's disease.
技术数据 for Salbutamol hemisulfate
| 分子量 | 288.35 |
| 公式 | C13H21NO3.½H2SO4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 51022-70-9 |
| PubChem ID | 39859 |
| InChI Key | BNPSSFBOAGDEEL-UHFFFAOYSA-N |
| Smiles | OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Salbutamol hemisulfate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 28.84 | 100 |
制备储备液 for Salbutamol hemisulfate
以下数据基于产品分子量 288.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.47 mL | 17.34 mL | 34.68 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.47 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
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产品说明书 for Salbutamol hemisulfate
参考文献 for Salbutamol hemisulfate
参考文献是支持产品生物活性的出版物。
January et al (1998) Salmeterol-induced desensitisation, internalization and phosphorylation of the human β2-adrenoceptor. Br.J.Pharmacol. 123 701 PMID: 9517390
Prior et al (1998) Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br.J.Pharmacol. 123 558 PMID: 9504397
Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373 PMID: 8979772
Merck Index 12 217
Fletcher et al (2019) Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats. Sci.Rep. 9 PMID: 31171821
Baker (2005) The selectivity of beta-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 15655528
If you know of a relevant reference for Salbutamol hemisulfate, please let us know.
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关键词: Salbutamol hemisulfate, Salbutamol hemisulfate supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, agonists, β-adrenergic, beta-adrenergic, b-adrenergic, receptors, albuterol, beta2, b2, parkinsons, Albuterol, Adrenergic, Beta-2, Receptors, 0634, Tocris Bioscience
6 篇 Salbutamol hemisulfate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Salbutamol hemisulfate 的部分引用包括：
Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688
Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol 165 2672 PMID: 21883146
Picard et al (2018) Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol 1 106 PMID: 30271986
Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672
Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319
Baker (2005) The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 1565552
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.