Sanguinarine chloride

Cat. No. 2302 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibitor of protein phosphatase 2C (PP2C)

化学名： 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride

纯度： ≥97% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Sanguinarine chloride

Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC₅₀ = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G₁ phase; inhibits cell growth in human prostate carcinoma cells.

技术数据 for Sanguinarine chloride

分子量	367.78
公式	C₂₀H₁₄ClNO₄
储存	Store at +4°C
纯度	≥97% (HPLC)
CAS Number	5578-73-4
PubChem ID	68635
InChI Key	GIZKAXHWLRYMLE-UHFFFAOYSA-M
Smiles	C[N+]1=CC4=C(C=CC5=C4OCO5)C3=C1C2=CC(OCO6)=C6C=C2C=C3.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sanguinarine chloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	3.68	10

制备储备液 for Sanguinarine chloride

以下数据基于产品分子量 367.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	27.19 mL	135.95 mL	271.9 mL
0.5 mM	5.44 mL	27.19 mL	54.38 mL
1 mM	2.72 mL	13.6 mL	27.19 mL
5 mM	0.54 mL	2.72 mL	5.44 mL

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产品说明书 for Sanguinarine chloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sanguinarine chloride

参考文献是支持产品生物活性的出版物。

Vogt et al (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 280 19078 PMID: 15753082

Aburai et al (2010) Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 74 548 PMID: 20208361

Adhami et al (2004) Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther. 3 934

If you know of a relevant reference for Sanguinarine chloride, please let us know.

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