SAR 7334

Cat. No. 5831 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent TRPC6 inhibitor

化学名： 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SAR 7334

SAR 7334 is a potent TRPC6 inhibitor (IC₅₀ values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca²⁺ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.

技术数据 for SAR 7334

分子量	440.79
公式	C₂₁H₂₂ClN₃O.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1333207-63-8
PubChem ID	78357800
InChI Key	LFMYIKNZNTZSJX-IQJQELQDSA-N
Smiles	N[C@@H]1CCCN([C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(C=C(C#N)C=C4)Cl)C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SAR 7334

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	44.08	100
	DMSO	44.08	100

制备储备液 for SAR 7334

以下数据基于产品分子量 440.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.34 mL	22.69 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for SAR 7334

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SAR 7334

参考文献是支持产品生物活性的出版物。

Maier et al (2015) Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br.J.Pharmacol. 172 3650 PMID: 25847402

If you know of a relevant reference for SAR 7334, please let us know.

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关键词: SAR 7334, SAR 7334 supplier, SAR7334, potent, transient, receptor, potential, canonical, channel, TRPC6, inhibitors, inhibits, orally, bioavailable, hypoxic, pulmonary, vasoconstriction, hpv, TRPC, 5831, Tocris Bioscience