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Submit ReviewSarafotoxin S6c
说明： Selective ETB agonist
纯度： ≥95% (HPLC)
生物活性 for Sarafotoxin S6c
Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).
技术数据 for Sarafotoxin S6c
| 分子量 | 2516 |
| 公式 | C103H147N27O37S5 |
| 序列 |
CTCNDMTDEECLNFCHQDVIW (Modifications: Disulfide bridges: 1-15, 3-11) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 121695-87-2 |
| PubChem ID | 71456935 |
| InChI Key | LXPHPKVWHQLBBA-JHOSIGDNSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Sarafotoxin S6c
参考文献 for Sarafotoxin S6c
参考文献是支持产品生物活性的出版物。
Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905 PMID: 9023305
Miasiro et al (1998) Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. J.Cardiovasc.Pharmacol. 31 S175 PMID: 9595431
Williams et al (1991) Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 175 556 PMID: 1850245
Williams et al (1993) Characterization of cloned human endothelin receptors. Life Sci. 53 407 PMID: 8336519
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关键词: Sarafotoxin S6c, Sarafotoxin S6c supplier, Selective, ETB, agonists, receptors, endothelin, SarafotoxinS6c, venoms, Endothelin, Receptors, 1175, Tocris Bioscience
2 篇 Sarafotoxin S6c 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Sarafotoxin S6c 的部分引用包括：
Hein et al (2009) Functional and molecular characterization of the endothelin system in retinal arterioles. Br J Pharmacol 50 3329 PMID: 19151386
Ou et al (2014) Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol 229 489 PMID: 24105843
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