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Submit ReviewSB 205384
说明： GABAA modulator; slows current decay
化学名： 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester
纯度： ≥98% (HPLC)
生物活性 for SB 205384
SB 205384 is a GABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.
技术数据 for SB 205384
| 分子量 | 330.4 |
| 公式 | C17H18N2O3S |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 160296-13-9 |
| PubChem ID | 197690 |
| InChI Key | JDTZAGLGBRRCJT-UHFFFAOYSA-N |
| Smiles | CC#CCOC(=O)C1=C(C)N=C2SC3=C(CCC(O)C3)C2=C1N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SB 205384
参考文献 for SB 205384
参考文献是支持产品生物活性的出版物。
Meadows et al (1997) Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 121 1334 PMID: 9257911
Meadows et al (1998) SB-205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 123 1253 PMID: 9559912
Hutcheon et al (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 522 3 PMID: 10618148
Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with J.Pharmacol.Exp.Ther. 347 235 PMID: 23902941
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关键词: SB 205384, SB 205384 supplier, GABAA, receptor, modulators, slows, current, decay, Receptors, SB205384, 1512, Tocris Bioscience
2 篇 SB 205384 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SB 205384 的部分引用包括：
Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther 347 235 PMID: 23902941
Miller et al (2010) Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Sci Rep 21 247 PMID: 20512339
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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