SB 290157 trifluoroacetate

Cat. No. 6860 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent C3a receptor antagonist

化学名： N²-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate

纯度： ≥97% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 290157 trifluoroacetate

SB 290157 trifluoroacetate is a potent C3a receptor antagonist (IC₅₀ values are 27 - 30 nM for C3a-induced Ca²⁺ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets. Also exhibits C3a receptor agonist activity.

技术数据 for SB 290157 trifluoroacetate

分子量	526.51
公式	C₂₂H₂₈N₄O₄.CF₃CO₂H
储存	Desiccate at RT
纯度	≥97% (HPLC)
CAS Number	1140525-25-2
PubChem ID	16760645
InChI Key	ZJRMPPVJAQWGEG-FYZYNONXSA-N
Smiles	NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 290157 trifluoroacetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	52.65	100
	ethanol	52.65	100

制备储备液 for SB 290157 trifluoroacetate

以下数据基于产品分子量 526.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.9 mL	9.5 mL	18.99 mL
5 mM	0.38 mL	1.9 mL	3.8 mL
10 mM	0.19 mL	0.95 mL	1.9 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for SB 290157 trifluoroacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 290157 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Ames et al (2001) Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J.Immunol. 166 6341 PMID: 11342658

Atanes et al (2018) C3aR and C5aR1 act as key regulators of human and mouse β-cell function. Cell Mol.Life Sci. 75 715 PMID: 28921001

Hu et al (2019) Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways. Eur.J.Pharmacol. 850 135 PMID: 30771350

Mathieu et al (2005) The C3a receptor antagonist SB 290157 has agonist activity. Immunol.Lett. 100 139 PMID: 16154494

If you know of a relevant reference for SB 290157 trifluoroacetate, please let us know.

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2 篇 SB 290157 trifluoroacetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 290157 trifluoroacetate 的部分引用包括：

Yu et al (2022) C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models. Cancer Immunol Res 10 245-258 PMID: 34819308

Sarah Y et al (2020) Gut Ischemia Reperfusion Injury Induces Lung Inflammation via Mesenteric Lymph-Mediated Neutrophil Activation. Front Immunol 11 586685 PMID: 33042165

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