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Submit ReviewSC 57461A
Discontinued Product
3107 has been discontinued.
View all Leukotriene A<sub>4</sub> Hydrolase products.
说明： Selective inhibitor of LTA4 hydrolase
化学名： N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for SC 57461A
SC 57461A is a potent and selective inhibitor of LTA4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. Potently inhibits LTB4 production in whole blood (IC50 = 49 nM). Orally active.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for SC 57461A
| 分子量 | 363.88 |
| 公式 | C20H25NO3.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 423169-68-0 |
| PubChem ID | 9820433 |
| InChI Key | SBBJJLDNKNNWFJ-UHFFFAOYSA-N |
| Smiles | CN(CCC(O)=O)CCCOC(C=C2)=CC=C2CC1=CC=CC=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SC 57461A
参考文献 for SC 57461A
参考文献是支持产品生物活性的出版物。
Penning et al (2002) Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. J.Med.Chem. 45 3482 PMID: 12139459
Askonas et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase I: in vitro studies. J.Pharmacol.Exp.Ther. 300 577 PMID: 11805219
Kachur et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase II: in vivo studies. J.Pharmacol.Exp.Ther. 300 583 PMID: 11805220
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关键词: SC 57461A, SC 57461A supplier, Selective, inhibitors, inhibits, LTA4, hydrolases, SC57461A, Pfizer, Hydrolase, Aminopeptidases, 3107, Tocris Bioscience
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