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Submit ReviewSCH 51344
说明： Potent MTH1 inhibitor
化学名： 2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
纯度： ≥99% (HPLC)
生物活性 for SCH 51344
SCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.
技术数据 for SCH 51344
| 分子量 | 316.35 |
| 公式 | C16H20N4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 171927-40-5 |
| PubChem ID | 9995890 |
| InChI Key | YWEGXZZAORIRQR-UHFFFAOYSA-N |
| Smiles | CC1=NN=C(N3)C1=C(NCCOCCO)C2=C3C=CC(OC)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SCH 51344
参考文献 for SCH 51344
参考文献是支持产品生物活性的出版物。
Walsh et al (1997) SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene 15 2553 PMID: 9399643
Kumar et al (1999) SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway. Ann.N.Y.Acad.Sci. 886 122 PMID: 10667210
Huber et al (2014) Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508 222 PMID: 24695225
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关键词: SCH 51344, SCH 51344 supplier, SCH51344, potent, MTH1, inhibitors, inhibits, ras, transformation, anticancer, hydrolases, g, proteins, mutT, homologue, NUDT1, MutT, homolog-1, (MTH1), 5280, Tocris Bioscience
1 篇 SCH 51344 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SCH 51344 的部分引用包括：
Andrzej et al (2022) 1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research. Molecules 27 PMID: 35566124
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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