Scopolamine hydrobromide

Cat. No. 1414 17 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Non-selective muscarinic antagonist

化学名： (α,S)-α-(Hydroxymethyl)benzeneacetic acid (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester hydrobromide

纯度： ≥99% (HPLC)

引用文献 (17)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Scopolamine hydrobromide

Scopolamine hydrobromide is a non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

技术数据 for Scopolamine hydrobromide

分子量	384.27
公式	C₁₇H₂₁NO₄.HBr
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	114-49-8
PubChem ID	45073445
InChI Key	WMRMIRRDPBKNMY-ZEECNFPPSA-N
Smiles	O=C([C@@H]([C@]3=CC=CC=C3)CO)O[C@H]1C[C@H]4[C@H](O2)[C@H]2[C@H](N4C)C1.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Scopolamine hydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	38.43	100
	DMSO	19.21	50

制备储备液 for Scopolamine hydrobromide

以下数据基于产品分子量 384.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.6 mL	13.01 mL	26.02 mL
5 mM	0.52 mL	2.6 mL	5.2 mL
10 mM	0.26 mL	1.3 mL	2.6 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for Scopolamine hydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Scopolamine hydrobromide

参考文献是支持产品生物活性的出版物。

Jones and Shannon (2000) Effects of scopol. in comparison with apomor. and phencyclidine on prepulse inhibition in rats. Eur.J.Pharmacol. 391 105 PMID: 10720641

Nakao et al (1999) Cerebral blood flow responses to somatosensory stimulation are unaffected by scopol. in unanesthetized rat. J.Pharmacol.Exp.Ther. 290 929 PMID: 10411611

Parkes (1965) An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atr. and some synthetic basic esters. Psychopharmacologia 7 1 PMID: 5830966

If you know of a relevant reference for Scopolamine hydrobromide, please let us know.

按标靶查看相关产品

关键词: Scopolamine hydrobromide, Scopolamine hydrobromide supplier, Non-Selective, muscarinic, antagonist, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 1414, Tocris Bioscience

17 篇 Scopolamine hydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Scopolamine hydrobromide 的部分引用包括：

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Front Behav Neurosci 4 PMID: 25723967

Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914

Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439

Field et al (2012) Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci 32 6288 PMID: 22553034

Marcott et al (2014) Phasic DA release drives rapid activation of striatal D2-receptors. Neuron 84 164 PMID: 25242218

Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155 PMID: 21544206

Chuhma et al (2014) DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling. Elife 81 901 PMID: 24559678

Delcourte et al (2020) Astroglia in lateral habenula is essential for antidepressant efficacy of light. BioRXiv - not yet peer reviewed

Bali et al (2015) Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models. Brain Behav Res 278 404 PMID: 25447295

Chuhma et al (2009) DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068 PMID: 19729052

Bali et al (2019) Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats. Front Pharmacol 10 73 PMID: 30804787

Lecrux et al (2017) Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. J Neurosci 37 1518 PMID: 28069927

Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886

Cai & Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep 25 3148 PMID: 30540946

Herrera-Rincon et al (2017) The brain is required for normal muscle and nerve patterning during early Xenopus development. Nat Commun 8 587 PMID: 28943634

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