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说明： Histone deacetylase inhibitor
化学名： N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
纯度： ≥99% (HPLC)
生物活性 for Scriptaid
Scriptaid is a novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
技术数据 for Scriptaid
| 分子量 | 326.35 |
| 公式 | C18H18N2O4 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 287383-59-9 |
| PubChem ID | 5186 |
| InChI Key | JTDYUFSDZATMKU-UHFFFAOYSA-N |
| Smiles | ONC(=O)CCCCCN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Scriptaid
参考文献 for Scriptaid
参考文献是支持产品生物活性的出版物。
Su et al (2000) A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 60 3137 PMID: 10866300
关键词: Scriptaid, Scriptaid supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, Non-selective, HDACs, Non-Selective, 2421, Tocris Bioscience
2 篇 Scriptaid 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Scriptaid 的部分引用包括：
Sharma et al (2010) HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. J Cell Mol Med 14 2151 PMID: 19583803
Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J Cancer 118 1359 PMID: 29695769
Scriptaid 的评论
平均评分: 5 (Based on 1 Review.)
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TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot..
By
Anonymous on 11/15/2019
分析类型： In Vivo
种属： Mouse
细胞系/组织： C3-TAg tumour cell
TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.