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说明： Potent GABAA antagonist; β1-subunit selective
化学名： Salicylidene salicylhydrazide
生物活性 for SCS
SCS is a potent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.
技术数据 for SCS
| 分子量 | 256.26 |
| 公式 | C14H12N2O3 |
| 储存 | Store at RT |
| CAS Number | 3232-36-8 |
| PubChem ID | 252156309 |
| InChI Key | OMCYEZUIYGPHDJ-OQLLNIDSSA-N |
| Smiles | OC1=CC=CC=C1\C=N\NC(=O)C1=CC=CC=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SCS
参考文献 for SCS
参考文献是支持产品生物活性的出版物。
Thompson et al (2004) Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors. Br.J.Pharmacol. 142 97 PMID: 15100159
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关键词: SCS, SCS supplier, Selective, GABAA, receptor, antagonists, beta1-subunit-selective, Receptors, 2143, Tocris Bioscience
2 篇 SCS 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SCS 的部分引用包括：
Limon et al (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol 109 10071 PMID: 22691495
Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 16 8 PMID: 25887256
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.