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SD 169

Cat. No. 2938 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2938 has been discontinued.

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说明： Selective, orally active p38α inhibitor
化学名： 1H-Indole-5-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for SD 169

Selective, orally active, ATP-competitive inhibitor of p38α MAPK (IC50 values are 3.2, 122 and > 50000 nM for p38α, p38β and p38γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

技术数据 for SD 169

分子量 160.17
公式 C9H8N2O
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 1670-87-7
Smiles NC(C1=CC=C(NC=C2)C2=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SD 169

参考文献是支持产品生物活性的出版物。

Myers et al (2003) Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp.Neurol. 184 606 PMID: 14769353

Medicherla et al (2006) Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J.Pharmacol.Exp.Ther. 318 99 PMID: 16603672

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关键词: SD 169, SD 169 supplier, Selective, orally, active, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, p38, SD169, 2938, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SD 169

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.