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Submit ReviewSDM25N hydrochloride
Discontinued Product
1410 has been discontinued.
说明： High affinity and selective non-peptide δ antagonist; also inhibits dengue virus replication
化学名： (4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride
纯度： ≥99% (HPLC)
生物活性 for SDM25N hydrochloride
SDM25N hydrochloride is a high affinity and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). More selective than naltrindole (Cat. No. 0740). Also inhibits Dengue virus replication.
技术数据 for SDM25N hydrochloride
| 分子量 | 450.96 |
| 公式 | C26H26N2O3.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 342884-71-3 |
| PubChem ID | 90479789 |
| InChI Key | QLLCUVACGPLGAX-IDRHMUJXSA-N |
| Smiles | Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC(C)=C)[C@]([H])(C4)[C@]1(O)CC1=C2NC2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SDM25N hydrochloride
参考文献 for SDM25N hydrochloride
参考文献是支持产品生物活性的出版物。
McLamore et al (2001) Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2 ',3 '-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. J.Med.Chem. 44 1471 PMID: 11311071
Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. PMID: 28507028
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关键词: SDM25N hydrochloride, SDM25N hydrochloride supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, antagonist, DOP, Receptors, OP1, dengue, virus, antiviral, Delta, Opioid, Flaviviruses, 1410, Tocris Bioscience
3 篇 SDM25N hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SDM25N hydrochloride 的部分引用包括：
Ong et al (2015) Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking. Br J Pharmacol 172 615 PMID: 24819092
Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. 198 4764 PMID: 28507028
van Cleef et al (2013) Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Res. 99 165 PMID: 23735301
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