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SDZ 21009

Cat. No. 1516 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1516 has been discontinued.

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说明： β-adrenoceptor antagonist; also 5-HT1A and 5-HT1B antagonist
化学名： 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylic acid, 1-methylethyl ester
说明书
引用文献
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文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for SDZ 21009

SDZ 21009 is an β-adrenoceptor and 5-HT1A/1B receptor antagonist. pKB/pA2 values are 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors respectively. Centrally active following systemic administration in vivo.

技术数据 for SDZ 21009

分子量 348.44
公式 C19H28N2O4
储存 Store at RT
CAS Number 39731-05-0
PubChem ID 193949
InChI Key SJYFDORQYYEJLB-UHFFFAOYSA-N
Smiles CC(C)OC(=O)C1=CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SDZ 21009

参考文献是支持产品生物活性的出版物。

Chojnacka-Wojcik and Przegalinski (1991) Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats. Neuropharmacology 30 703 PMID: 1681448

Hoyer et al (1994) VII International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Engel et al (1986) Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmied.Arch.Pharmacol. 332 1

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关键词: SDZ 21009, SDZ 21009 supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, antagonists, 5-HT1A/1B, β-adrenergic, beta-adrenergic, b-adrenergic, Receptors, Non-Selective, Serotonin, SDZ21009, Non-selective, Adrenergic, Beta, 5-HT1A, 5-HT1B, 1516, Tocris Bioscience

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.