Senexin A

Cat. No. 4875 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Cdk8 inhibitor

化学名： 4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Senexin A

Senexin A is a cyclin-dependent kinase 8 (cdk8) inhibitor (IC₅₀ = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.

许可信息

Sold under license from Senex Biotechnology.

技术数据 for Senexin A

分子量	310.78
公式	C₁₇H₁₄N₄.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1780390-76-2
PubChem ID	90488980
InChI Key	POENYXHGUHRXFR-UHFFFAOYSA-N
Smiles	N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Senexin A

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	31.08	100

制备储备液 for Senexin A

以下数据基于产品分子量 310.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.09 mL	32.18 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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产品说明书 for Senexin A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Senexin A

参考文献是支持产品生物活性的出版物。

Porter et al (2012) Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc.Natl.Acad.Sci.U.S.A. 109 13799 PMID: 22869755

If you know of a relevant reference for Senexin A, please let us know.

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关键词: Senexin A, Senexin A supplier, cyclin, dependent, kinases, cdks, cdk8, cdk19, inhibits, inhibitors, p21, transcription, Cyclin-dependent, Kinase, Transcriptional, CDKs, 4875, Tocris Bioscience