SF 1670

Pricing Availability   Qty
说明: PTPN2 and PTEN inhibitor
别名: PTP Inhibitor XIX
化学名: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
纯度: ≥98% (HPLC)
说明书
引用文献 (2)
评论

生物活性 for SF 1670

SF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

技术数据 for SF 1670

分子量 307.34
公式 C19H17NO3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 345630-40-2
PubChem ID 9926586
InChI Key VZQDDSYKVYARDW-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SF 1670

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.73 100

制备储备液 for SF 1670

以下数据基于产品分子量 307.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Reconstitution Calculator

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关键词: SF 1670, SF 1670 supplier, SF1670, PTEN, inhibitors, phosphatase, tensin, homolog, deleted, chromosome, 10, neutrophils, transfusion, inhibits, PTPN2, CD45, cancer, immunotherapy, PTP, Inhibitor, XIX, Protein, Tyrosine, Phosphatases, 5020, Tocris Bioscience

2 篇 SF 1670 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SF 1670 的部分引用包括:

Lei et al (2017) Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. J Cell Biol 216 2551 PMID: 28659327

Gail A et al (2022) TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22. Sci Signal 15 eabn5507 PMID: 36166512


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