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Submit ReviewSF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.
分子量 | 307.34 |
公式 | C19H17NO3 |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 345630-40-2 |
PubChem ID | 9926586 |
InChI Key | VZQDDSYKVYARDW-UHFFFAOYSA-N |
Smiles | O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 30.73 | 100 |
以下数据基于产品分子量 307.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
参考文献是支持产品生物活性的出版物。
Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702 PMID: 21521784
Le et al (2017) Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep. 50 329 PMID: 28228214
If you know of a relevant reference for SF 1670, please let us know.
关键词: SF 1670, SF 1670 supplier, SF1670, PTEN, inhibitors, phosphatase, tensin, homolog, deleted, chromosome, 10, neutrophils, transfusion, inhibits, PTPN2, CD45, cancer, immunotherapy, PTP, Inhibitor, XIX, Protein, Tyrosine, Phosphatases, 5020, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 SF 1670 的部分引用包括:
Lei et al (2017) Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. J Cell Biol 216 2551 PMID: 28659327
Gail A et al (2022) TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22. Sci Signal 15 eabn5507 PMID: 36166512
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