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Submit ReviewSGS 518 oxalate
说明： Selective 5-HT6 antagonist
别名： LY 483518
化学名： 1-Methyl-3-(1-methyl-4-piperindin-4-yl)-5-hydroxy-1H-indole 2,6-difluorobenzenesulfonic acid ester oxalate
纯度： ≥98% (HPLC)
生物活性 for SGS 518 oxalate
SGS 518 oxalate is a selective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.
技术数据 for SGS 518 oxalate
| 分子量 | 510.51 |
| 公式 | C21H22F2N2O3S.C2H2O4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 445441-27-0 |
| PubChem ID | 24880040 |
| InChI Key | XQGFYENETWVJEU-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C(OS(C4=C(F)C=CC=C4F)(=O)=O)C=C1C(C3CCN(C)CC3)=C2.OC(C(O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SGS 518 oxalate
参考文献 for SGS 518 oxalate
参考文献是支持产品生物活性的出版物。
Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197 PMID: 18044950
Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133 PMID: 16865095
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关键词: SGS 518 oxalate, SGS 518 oxalate supplier, SGS518, 5-HTreceptors, serotonin, antagonists, schizophrenia, Alzheimers, LY483518, LY, 483518, 5-HT6, Receptors, 3688, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.