SI-2 hydrochloride

Cat. No. 5964 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Steroid receptor coactivator 3 (SRC-3) inhibitor

化学名： 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SI-2 hydrochloride

SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC₅₀ = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

技术数据 for SI-2 hydrochloride

分子量	301.78
公式	C15H15N5.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1992052-49-9
PubChem ID	121513909
InChI Key	CDYJHORKRVKALB-NWBUNABESA-N
Smiles	CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SI-2 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	15.09	50
	DMSO	6.04	20

制备储备液 for SI-2 hydrochloride

以下数据基于产品分子量 301.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	6.63 mL	33.14 mL	66.27 mL
2.5 mM	1.33 mL	6.63 mL	13.25 mL
5 mM	0.66 mL	3.31 mL	6.63 mL
25 mM	0.13 mL	0.66 mL	1.33 mL

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产品说明书 for SI-2 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SI-2 hydrochloride

参考文献是支持产品生物活性的出版物。

Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID: 27084884

If you know of a relevant reference for SI-2 hydrochloride, please let us know.

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关键词: SI-2 hydrochloride, SI-2 hydrochloride supplier, steroid, receptor, coactivator-3, SRC3, inhibitors, inhibits, breast, cancers, orally, available, 223788-33-8, Other, Nuclear, Receptors, Histone, Acetyltransferases, Transcription, Factors, 5964, Tocris Bioscience

1 篇 SI-2 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SI-2 hydrochloride 的部分引用包括：

Wei et al (2021) SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning. J Biol Chem 297 101044 PMID: 34358562

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