SIB 1508Y maleate

Name: SIB 1508Y maleate
Brand: Tocris Bioscience
SKU: 4766

Cat. No. 4766 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4766 has been discontinued.

View all Nicotinic Receptors (Non-selective) products.

说明： Potent agonist of α4β2, α2β4, α4β4 and α3β4 nACh receptors

化学名： 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for SIB 1508Y maleate

SIB 1508Y maleate is a potent neuronal nicotinic ACh receptor agonist (EC₅₀ values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

技术数据 for SIB 1508Y maleate

分子量	302.33
公式	C₁₂H₁₄N₂.C₄H₄O₄
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	192231-16-6
PubChem ID	10968648
InChI Key	BCPPKHPWLRPWBJ-OURKGEEVSA-N
Smiles	CN1CCC[C@H]1[C@]2=CC(C#C)=CN=C2.O=C(\C=C/C(O)=O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SIB 1508Y maleate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SIB 1508Y maleate

参考文献是支持产品生物活性的出版物。

Cosford et al (1996) (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 3235 PMID: 8765504

Schneider et al (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 290 731 PMID: 10411585

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