Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSIB 1553A hydrochloride
Discontinued Product
4764 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
说明： nAChR agonist; displays selectivity for β4 subunit-containing receptors
化学名： (±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for SIB 1553A hydrochloride
SIB 1553A hydrochloride is a nicotinic acetylcholine receptor (nAChR) agonist. Displays selectivity for β4 subunit-containing receptors. Stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes. Improves attention deficits and memory performance in a Parkinson's disease model.
技术数据 for SIB 1553A hydrochloride
| 分子量 | 273.82 |
| 公式 | C13H19NOS.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 191611-89-9 |
| PubChem ID | 9881989 |
| InChI Key | RJSVKPQKXSMZMT-UHFFFAOYSA-N |
| Smiles | CN1CCCC1CCSC2=CC=C(O)C=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SIB 1553A hydrochloride
参考文献 for SIB 1553A hydrochloride
参考文献是支持产品生物活性的出版物。
Vernier et al (1999) 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 42 1684 PMID: 10346920
Rao et al (2003) In vitro pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 981 85 PMID: 12885429
Schneider et al (2003) The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys. J.Pharmacol.Exp.Ther. 306 401 PMID: 12721323
按产品操作查看相关产品
关键词: SIB 1553A hydrochloride, SIB 1553A hydrochloride supplier, SIB1553A, hydrochloride, SIB, 1553A, HCl, Nicotinic, acetylcholine, receptors, nAChR, agonist, cognitive, memory, Parkinson's, Alzheimer's, diseases, Receptors, (Other, Subtypes), 4764, Tocris Bioscience
SIB 1553A hydrochloride 的评论
目前没有该产品的评论。 Be the first to review SIB 1553A hydrochloride and earn rewards!
Have you used SIB 1553A hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.