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SID 7969543

Cat. No. 3440 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
化学名： Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SID 7969543

SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).

技术数据 for SID 7969543

分子量 452.46
公式 C24H24N2O7
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 868224-64-0
PubChem ID 4076092
InChI Key KWMBIIQCLUIHDI-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC(OC(C)C(OCC)=O)=C1C=CN2CC(NC3=CC=C(OCCO4)C4=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SID 7969543

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.25 100

制备储备液 for SID 7969543

以下数据基于产品分子量 452.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for SID 7969543

参考文献是支持产品生物活性的出版物。

Roth et al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 18 2628 PMID: 18374567

Madoux et al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776 PMID: 18334597

If you know of a relevant reference for SID 7969543, please let us know.

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关键词: SID 7969543, SID 7969543 supplier, Selective, steroidogenic, factor-1, SF-1, NR5A1, inhibitors, inhibits, Nuclear, Receptors, Steroidogenic, Factor-1, SID7969543, Other, 3440, Tocris Bioscience

1 篇 SID 7969543 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SID 7969543 的部分引用包括：

Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734

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