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SIN-1 chloride

Cat. No. 0756 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Water-soluble NO donor
别名： 3-Morpholinylsydnoneimine chloride
化学名： Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SIN-1 chloride

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

技术数据 for SIN-1 chloride

分子量 206.63
公式 C6H11ClN4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 16142-27-1
PubChem ID 197942
InChI Key ZRFWHHCXSSACAW-UHFFFAOYSA-M
Smiles NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SIN-1 chloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 20.66 100
DMSO 20.66 100

制备储备液 for SIN-1 chloride

以下数据基于产品分子量 206.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.84 mL 24.2 mL 48.4 mL
5 mM 0.97 mL 4.84 mL 9.68 mL
10 mM 0.48 mL 2.42 mL 4.84 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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产品说明书 for SIN-1 chloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for SIN-1 chloride

参考文献是支持产品生物活性的出版物。

Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671 PMID: 2160060

Nishikawa et al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183 PMID: 6118429

Siegfried et al (1992) Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 260 668 PMID: 1738117

Tanayama et al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4 175

If you know of a relevant reference for SIN-1 chloride, please let us know.

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关键词: SIN-1 chloride, SIN-1 chloride supplier, Water-soluble, NO, donor, Guanylyl, cyclases, activators, ROS, Donors, sGC, Precursors, Nitric, Oxide, Signaling, Signalling, vasodilator, 3-Morpholinylsydnoneimine, chloride, /, Cyclase, 0756, Tocris Bioscience

1 篇 SIN-1 chloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SIN-1 chloride 的部分引用包括：

Mistry and Garland (1998) Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery. Br J Pharmacol 124 1131 PMID: 9720783

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SIN-1 inhibits the chlorinating activity of MPO.
By Christopher Trummer on 10/15/2018
分析类型： In Vitro
种属： Other

Effects of SIN-1 (20 μM in pH 7.4, kept at 37 °C for 2 h) on the MPO (10 nM)-H2O2 (25 μM)-chloride system were analyzed by APF fluorescence measurements. Fluorescence intensities were measured every 30 s (up to 30 min) at 488/522 nm (excitation/emission wavelength) at 37 °C. SIN-1 inhibits the chlorinating capacity of MPO.

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